English

武石　直樹

博士（医工学）

准教授

京都工芸繊維大学

機械工学系

計算バイオメカニクス研究室

Email: ntakeishi_at_kit.ac.jp


研究について

コンピュータ・シミュレーション技術を用いて、1).生体内複雑流動（微小循環、気管内流動、血栓形成など）に関する力学原理の解明、2).医学・生物学的知見を工学的観点から再構築、3).各種疾患の新しい予測・診断・治療方法の創出に向けた基礎知見の提示を目指しています。


* denotes corresponding author

論文

    査読付国際雑誌

  1. Numerical-experimental estimation of the deformability of human red blood cells from rheometrical data .
    Naoki Takeishi∗, Tomohiro Nishiyama, Kodai Nagaishi, Takeshi Nashima, Masako Sugihara-Seki. Submitted.

  2. Title will be here.
    Sayaka Deguchi∗, Kaori Kosugi, Naoki Takeishi, Yukio Watanabe, Shiho Morimoto, Ryosuke Negoro, Fuki Yokoi, Hiroki Futatsusako, May Nakajima-Koyama, Mio Iwasaki, Takuya Yamamoto, Yoshiya Kawaguchi, Yu-suke Torisawa, Kazuo Takayama∗. Under revision.

  3. Phase changes of the flow rate in the vertebral artery caused by debranching thoracic endovascular aortic repair: effects of flow path and local vessel stiffness on vertebral arterial pulsation.
    Naoki Takeishi∗, Li Jialong, Naoto Yokoyama, Hisashi Tanaka, Takasumi Goto, Shigeo Wada. Under revision.

  4. Numerical analysis of viscoelasticity of two-dimensional fluid membranes under oscillatory tensile loadings.
    Naoki Takeishi∗, Masaya Santo, Naoto Yokoyama, Shigeo Wada. Under revision. https://doi.org/10.48550/arXiv.2210.11074.

  5. Viscoelasticity of suspension of red blood cells under oscillatory shear flow.
    Naoki Takeishi∗, Marco E. Rosti, Naoto Yokoyama, Luca Brandt. Phys. Fluids 2024, 36:041905, https://doi.org/10.1063/5.0196272.

  6. Enhanced axial migration of a deformable capsule in pulsatile channel flows.
    Naoki Takeishi∗, Marco E. Rosti∗. Phys. Rev. Fluids 2023, 8:L061101, https://doi.org/10.1103/PhysRevFluids.8.L061101.

  7. Inertial migration of red blood cells under a Newtonian fluid in a circular channel.
    Naoki Takeishi∗, Hiroshi Yamashita, Toshihiro Omori, Naoto Yokoyama, Shigeo Wada, Masako Sugihara-Seki. J. Fluid. Mech. 2022, 952:A35, https://doi.org/10.1017/jfm.2022.936.

  8. Computational fluid dynamics assessment of congenital tracheal stenosis.
    Keiichi Morita∗, Naoki Takeishi, Shigeo Wada, Tadashi Hatakeyama. Pediatr. Surg. Int. 2022, 38:1769-1776, https://doi.org/10.1007/s00383-022-05228-6.

  9. Fluid dynamic assessment of positive end-expiratory pressure in a tracheostomy tube connector during respiration.
    Shiori Kageyama, Naoki Takeishi∗, Hiroki Taenaka, Takeshi Yoshida, Shigeo Wada. Med. Biol. Eng. Comput. 2022, 60:2981-2993, https://doi.org/10.1007/s11517-022-02649-2.

  10. Airway performance in infants with congenital tracheal stenosis associated with unilateral pulmonary agenesis: effect of tracheal shape on energy flux.
    Shiori Kageyama, Naoki Takeishi∗, Naoki Harada, Kao Taniguchi, Keiichi Morita, Shigeo Wada. Med. Biol. Eng. Comput. 2022, 60:2335-2348, https://doi.org/10.1007/s11517-022-02601-4.

  11. Assessment of cardiac function using modified ejection fraction as an indicator of myocardial circumferential strain.
    Takaomi Morishita∗, Naoki Takeishi, Satoshi Ii, Shigeo Wada. J. Biomech. Sci. Eng. 2022, 17(2):22-00014, https://doi.org/10.1299/jbse.22-00014.

  12. Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation.
    Naoki Takeishi, Taiki Shigematsu, Ryogo Enosaki, Shunichi Ishida, Satoshi Ii∗, Shigeo Wada. J. R. Soc. Interface. 2021, 18(184):20210554, https://doi.org/10.1098/rsif.2021.0554.

  13. Axial and nonaxial migration of red blood cells in a microtube.
    Naoki Takeishi∗, Hiroshi Yamashita, Toshihiro Omori, Naoto Yokoyama, Masako Sugihara-Seki. Micromachines. 2021, 12(10):1162, https://doi.org/10.3390/mi12101162.

  14. Cerebrospinal fluid flow driven by arterial pulsations in axisymmetric perivascular spaces: analogy with Taylor's swimming sheet.
    Naoto Yokoyama∗, Naoki Takeishi, Shigeo Wada. J. Theol. Biol. 2021, 523:110709, https://doi.org/10.1016/j.jtbi.2021.110709.

  15. Effects of left ventricular hypertrophy and myocardial stiffness on myocardial strain under preserved ejection fraction.
    Takaomi Morishita, Naoki Takeishi, Satoshi Ii, Shigeo Wada∗. Ann. Biomed. Eng. 2021, 49:1670–1687, https://doi.org/10.1007/s10439-020-02706-7.

  16. Haemorheology in dilute, semi-dilute and dense suspensions of red blood cells.
    Naoki Takeishi∗, Marco E. Rosti, Yohsuke Imai, Shigeo Wada, Luca Brandt. J. Fluid. Mech. 2019, 872:818-848, https://doi.org/10.1017/jfm.2019.393.

  17. Capture event of platelets by bolus flow of red blood cells in capillaries.
    Naoki Takeishi∗, Yohsuke Imai, Shigeo Wada. J. Biomech. Sci. Eng. 2019, 14(3):18-00535, https://doi.org/10.1299/jbse.18-00535.

  18. Deformation of a red blood cell in a narrow rectangular microchannel.
    Naoki Takeishi∗, Hiroaki Ito, Makoto Kaneko, Shigeo Wada. Micromachines 2019, 10(3):199, https://doi.org/10.3390/mi10030199.

  19. Fluid dynamic assessment of tracheal flow in infants with congenital tracheal stenosis before and after surgery.
    Naoki Takeishi, Tomohiro Miki, Tomohito Otani, Satoshi Ii, Keiichi Morita, Shigeo Wada∗. Med. Biol. Eng. Comput. 2019, 57:837-847, https://doi.org/10.1007/s11517-018-1928-7.

  20. Capture of microparticles by bolus flow of red blood cells in capillaries.
    Naoki Takeishi, Yohsuke Imai∗. Sci. Rep. 2017, 7:5381, https://doi.org/10.1038/s41598-017-05924-7.

  21. Cell adhesion during bullet motion in capillaries.
    Naoki Takeishi, Yohsuke Imai∗, Shunichi Ishida, Toshihiro Omori, Roger D. Kamm, Takuji Ishikawa. Am. J. Physiol. Heart & Circ. Physiol. 2016, 311(2):H395-H403, https://doi.org/10.1152/ajpheart.00241.2016.

  22. Flow of a circulating tumor cell and red blood cells in microvessels.
    Naoki Takeishi, Yohsuke Imai∗, Takami Yamaguchi, Takuji Ishikawa. Phys. Rev. E 2015, 92(6):063011, https://doi.org/10.1103/PhysRevE.92.063011.

  23. Leukocyte margination at arteriole shear rate.
    Naoki Takeishi, Yohsuke Imai∗, Keita Nakaaki, Takami Yamaguchi, Takuji Ishikawa. Physiol. Rep. 2014, 2(6):e12037, https://doi.org/10.14814/phy2.12037.

    24. 査読付国内雑誌

  24. 多孔質体都市モデルによる局地気象現象の新しい数値予測.
    桑原不二朗, 武石直樹. 日本機械学会論文集B編 2011, 77(783):2181-2190, https://doi.org/10.1299/kikaib.77.2181.

    査読付国際会議論文

  1. How to measure cellular shear modulus inside a chip: detailed correspondence to the fluid-structure coupling analysis.
    Hiroaki Ito∗, Naoki Takeishi, Atsushi Kirimoto, Misato Chimura, Tomohito Ohtani, Yasushi Sakata, Mitsuhiro Horade, Toshio Takayama, Makoto Kaneko. 2019 IEEE 32nd International Conference on Micro Electro Mechanical System (Seoul, Korea) 2019, doi:10.1109/MEMSYS.2019.8870772.

  2. Development of a numerical model for micro-scale blood flow simulation using GPGPU.
    Naoki Takeishi, Yohsuke Imai∗, Takuji Ishikawa, Takami Yamaguchi. ASME 2012 Summer Bioengineering Conference (Fajardo, Puerto Rico, USA). 2013, Paper No:SBC2012-80028, pp.823-824, doi:10.1115/SBC2012-80028.

書籍

  1. 医用工学ハンドブック(第2編:医用工学の基礎知識 第3章:シミュレーション 4節:微小循環系のマルチスケールバイオメカニクス).
    武石直樹, 和田成生（[編集代表] 佐久間一郎, [編集幹事] 秋吉一成, 津本浩平）.
    2022年2月(ISBN-13:978-4860437350). NTS.

  2. 医療に活かす生体医工学 (第2章:生体力学シミュレーション).
    和田成生, 伊井仁志, 大谷智仁, 武石直樹.
    2020年11月(ISBN-13:978-4-339-07247-1). 日本生体医工学会[編], コロナ社.

総説・解説記事

  1. 【ポスト「京」重点課題2 -個別化・予防医療を支援する統合計算生命科学-】脳微小循環のダイナミクスと脳機能.
    武石直樹, 正本和人, 伊井仁志, 和田成生. News Letter, Vol.19, 1-7, 2019.

  2. 【特集：固液・気液二相流の対流・物質輸送】血球細胞と対流物質輸送.
    武石直樹, 伊井仁志, 和田成生. 伝熱2019年1月号, 58巻242号, 22-29, 2019.

  3. 【特集：注目研究in年会2018】赤血球希薄懸濁液と濃厚懸濁液のレオロジーを繋ぐ数値解析.
    武石直樹, Marco E. Rosti, 今井陽介, 和田成生, Luca Brandt. ながれ2018年12月号, 37巻6号, 516-519, 2018.

  4. 【海外混相流事情】血液レオロジーの数値解析に関する国際共同研究 (スウェーデン王立工科大学にて).
    武石直樹. 混相流2018年12月号, 32巻4号, 454-457, 2018.

取材

  1. 【次世代の担い手たち】生命活動を支える生体内の流れを流体力学の視点で捉えたい.
    武石直樹. 日経サイエンス2018年4月号, 1-2, 2018.

  2. Interview with JSPS fellows in the U.S.
    Naoki Takeishi. JSPS San Francisco Newsletter, Vol. 34, p.11, Jul. 2014.