武石　直樹

研究について

コンピュータ・シミュレーション技術を用いて、1).生体内複雑流動（微小循環、気管内流動、血栓形成など）に関する力学原理の解明、2).医学・生物学的知見を工学的観点から再構築、3).各種疾患の新しい予測・診断・治療方法の創出に向けた基礎知見の提示を目指しています。

論文

査読付国際雑誌

1. Phase changes of the flow rate in the vertebral artery caused by debranching thoracic endovascular aortic repair: effects of flow path and local vessel stiffness on vertebral arterial pulsation.
   Naoki Takeishi^∗, Li Jialong, Naoto Yokoyama, Hisashi Tanaka, Takasumi Goto, Shigeo Wada. Under review.


2. Inertial focusing of spherical capsule in pulsatile channel flows.
   Naoki Takeishi^∗, Kenta Ishimoto, Naoto Yokoyama, Marco E. Rosti^∗. Under revision.


3. Spatiotemporal distribution of YAP and importin-β in nucleus and cytosol after wounding of adjacent cells.
   Boyuan Xiao, Saori, Sasaki, Naoki Takeishi, Toshihiro Sera, Susumu Kudo^∗. Under revision.


4. Microscale topographies on biomaterial surfaces modulate cell migration.
   Saori Sasaki^∗, Keita Eguchi, Ming Wei, Ryu Takahashi, Toshihiro Sera, Naoki Takeishi, Susumu Kudo^∗. J. Biorheol. 2024, Accepted.


5. Quantification of membrane protein diffusion on endothelial cell surfaces under shear stress using a photochromic fluorescent protein.
   Naoto Kawasaki, Keita Hamasaki, Saori Sasaki, Naoki Takeishi^∗, Susumu Kudo^∗. J. Biorheol. 2024, Accepted.


6. Numerical-experimental estimation of the deformability of human red blood cells from rheometrical data.
   Naoki Takeishi^∗, Tomohiro Nishiyama, Kodai Nagaishi, Takeshi Nashima, Masako Sugihara-Seki. J. Rheol. 2024, 68:837-848, https://doi.org/10.1122/8.0000877
   ▶ Featured article (Journal's Best)
   ▶ Scilight (Science Highlight)


7. Construction of multilayered small intestine-like tissue by reproducing interstitial flow.
   Sayaka Deguchi^∗, Kaori Kosugi, Naoki Takeishi, Yukio Watanabe, Shiho Morimoto, Ryosuke Negoro, Fuki Yokoi, Hiroki Futatsusako, May Nakajima-Koyama, Mio Iwasaki, Takuya Yamamoto, Yoshiya Kawaguchi, Yu-suke Torisawa, Kazuo Takayama^∗. Cell Stem Cell. 2024, 31:1-12, https://doi.org/10.1016/j.stem.2024.06.012.


8. Numerical analysis of viscoelasticity of two-dimensional fluid membranes under oscillatory loadings.
   Naoki Takeishi^∗, Masaya Santo, Naoto Yokoyama, Shigeo Wada. Results Eng. 2024, 22:102304, https://doi.org/10.1016/j.rineng.2024.102304.


9. Viscoelasticity of suspension of red blood cells under oscillatory shear flow.
   Naoki Takeishi^∗, Marco E. Rosti, Naoto Yokoyama, Luca Brandt. Phys. Fluids 2024, 36:041905, https://doi.org/10.1063/5.0196272.


10. Enhanced axial migration of a deformable capsule in pulsatile channel flows.
    Naoki Takeishi^∗, Marco E. Rosti^∗. Phys. Rev. Fluids 2023, 8:L061101, https://doi.org/10.1103/PhysRevFluids.8.L061101.


11. Inertial migration of red blood cells under a Newtonian fluid in a circular channel.
    Naoki Takeishi^∗, Hiroshi Yamashita, Toshihiro Omori, Naoto Yokoyama, Shigeo Wada, Masako Sugihara-Seki. J. Fluid. Mech. 2022, 952:A35, https://doi.org/10.1017/jfm.2022.936.


12. Computational fluid dynamics assessment of congenital tracheal stenosis.
    Keiichi Morita^∗, Naoki Takeishi, Shigeo Wada, Tadashi Hatakeyama. Pediatr. Surg. Int. 2022, 38:1769-1776, https://doi.org/10.1007/s00383-022-05228-6.


13. Fluid dynamic assessment of positive end-expiratory pressure in a tracheostomy tube connector during respiration.
    Shiori Kageyama, Naoki Takeishi^∗, Hiroki Taenaka, Takeshi Yoshida, Shigeo Wada. Med. Biol. Eng. Comput. 2022, 60:2981-2993, https://doi.org/10.1007/s11517-022-02649-2.
    ▶ Highlight paper in the October 2022 issue of Med. Biol. Eng. Comput.


14. Airway performance in infants with congenital tracheal stenosis associated with unilateral pulmonary agenesis: effect of tracheal shape on energy flux.
    Shiori Kageyama, Naoki Takeishi^∗, Naoki Harada, Kao Taniguchi, Keiichi Morita, Shigeo Wada. Med. Biol. Eng. Comput. 2022, 60:2335-2348, https://doi.org/10.1007/s11517-022-02601-4.


15. Assessment of cardiac function using modified ejection fraction as an indicator of myocardial circumferential strain.
    Takaomi Morishita^∗, Naoki Takeishi, Satoshi Ii, Shigeo Wada. J. Biomech. Sci. Eng. 2022, 17(2):22-00014, https://doi.org/10.1299/jbse.22-00014.
    ▶ 2022 JBSE Papers of the Year Award


16. Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation.
    Naoki Takeishi, Taiki Shigematsu, Ryogo Enosaki, Shunichi Ishida, Satoshi Ii^∗, Shigeo Wada. J. R. Soc. Interface. 2021, 18(184):20210554, https://doi.org/10.1098/rsif.2021.0554.


17. Axial and nonaxial migration of red blood cells in a microtube.
    Naoki Takeishi^∗, Hiroshi Yamashita, Toshihiro Omori, Naoto Yokoyama, Masako Sugihara-Seki. Micromachines. 2021, 12(10):1162, https://doi.org/10.3390/mi12101162.
    ▶ Editorial for the Special Issue on Advances in Microfluidics for Quantifying Cell Mechanics and Biotransport.
    ▶ Special Issue (Editors: H.I and N.T) "Advances in Microfluidics for Quantifying Cell Mechanics and Biotransport"


18. Cerebrospinal fluid flow driven by arterial pulsations in axisymmetric perivascular spaces: analogy with Taylor's swimming sheet.
    Naoto Yokoyama^∗, Naoki Takeishi, Shigeo Wada. J. Theol. Biol. 2021, 523:110709, https://doi.org/10.1016/j.jtbi.2021.110709.


19. Effects of left ventricular hypertrophy and myocardial stiffness on myocardial strain under preserved ejection fraction.
    Takaomi Morishita, Naoki Takeishi, Satoshi Ii, Shigeo Wada^∗. Ann. Biomed. Eng. 2021, 49:1670–1687, https://doi.org/10.1007/s10439-020-02706-7.


20. Haemorheology in dilute, semi-dilute and dense suspensions of red blood cells.
    Naoki Takeishi^∗, Marco E. Rosti, Yohsuke Imai, Shigeo Wada, Luca Brandt. J. Fluid. Mech. 2019, 872:818-848, https://doi.org/10.1017/jfm.2019.393.
    ▶ Advances In ENGINEERING


21. Capture event of platelets by bolus flow of red blood cells in capillaries.
    Naoki Takeishi^∗, Yohsuke Imai, Shigeo Wada. J. Biomech. Sci. Eng. 2019, 14(3):18-00535, https://doi.org/10.1299/jbse.18-00535.


22. Deformation of a red blood cell in a narrow rectangular microchannel.
    Naoki Takeishi^∗, Hiroaki Ito, Makoto Kaneko, Shigeo Wada. Micromachines 2019, 10(3):199, https://doi.org/10.3390/mi10030199.


23. Fluid dynamic assessment of tracheal flow in infants with congenital tracheal stenosis before and after surgery.
    Naoki Takeishi, Tomohiro Miki, Tomohito Otani, Satoshi Ii, Keiichi Morita, Shigeo Wada^∗. Med. Biol. Eng. Comput. 2019, 57:837-847, https://doi.org/10.1007/s11517-018-1928-7.


24. Capture of microparticles by bolus flow of red blood cells in capillaries.
    Naoki Takeishi, Yohsuke Imai^∗. Sci. Rep. 2017, 7:5381, https://doi.org/10.1038/s41598-017-05924-7.


25. Cell adhesion during bullet motion in capillaries.
    Naoki Takeishi, Yohsuke Imai^∗, Shunichi Ishida, Toshihiro Omori, Roger D. Kamm, Takuji Ishikawa. Am. J. Physiol. Heart & Circ. Physiol. 2016, 311(2):H395-H403, https://doi.org/10.1152/ajpheart.00241.2016.


26. Flow of a circulating tumor cell and red blood cells in microvessels.
    Naoki Takeishi, Yohsuke Imai^∗, Takami Yamaguchi, Takuji Ishikawa. Phys. Rev. E 2015, 92(6):063011, https://doi.org/10.1103/PhysRevE.92.063011.
    ▶ Inside Science "Fast, Fluid Cells Spread Cancer"


27. Leukocyte margination at arteriole shear rate.
    Naoki Takeishi, Yohsuke Imai^∗, Keita Nakaaki, Takami Yamaguchi, Takuji Ishikawa. Physiol. Rep. 2014, 2(6):e12037, https://doi.org/10.14814/phy2.12037.



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査読付国内雑誌

28. 多孔質体都市モデルによる局地気象現象の新しい数値予測.
    桑原不二朗, 武石直樹. 日本機械学会論文集B編 2011, 77(783):2181-2190, https://doi.org/10.1299/kikaib.77.2181.



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査読付国際会議論文

1. How to measure cellular shear modulus inside a chip: detailed correspondence to the fluid-structure coupling analysis.
   Hiroaki Ito^∗, Naoki Takeishi, Atsushi Kirimoto, Misato Chimura, Tomohito Ohtani, Yasushi Sakata, Mitsuhiro Horade, Toshio Takayama, Makoto Kaneko. 2019 IEEE 32nd International Conference on Micro Electro Mechanical System (Seoul, Korea) 2019, doi:10.1109/MEMSYS.2019.8870772.


2. Development of a numerical model for micro-scale blood flow simulation using GPGPU.
   Naoki Takeishi, Yohsuke Imai^∗, Takuji Ishikawa, Takami Yamaguchi. ASME 2012 Summer Bioengineering Conference (Fajardo, Puerto Rico, USA). 2013, Paper No:SBC2012-80028, pp.823-824, doi:10.1115/SBC2012-80028.

書籍

1. 医用工学ハンドブック(第2編:医用工学の基礎知識 第3章:シミュレーション 4節:微小循環系のマルチスケールバイオメカニクス).
   武石直樹, 和田成生（[編集代表] 佐久間一郎, [編集幹事] 秋吉一成, 津本浩平）.
   2022年2月(ISBN-13:978-4860437350). NTS.


2. 医療に活かす生体医工学 (第2章:生体力学シミュレーション).
   和田成生, 伊井仁志, 大谷智仁, 武石直樹.
   2020年11月(ISBN-13:978-4-339-07247-1). 日本生体医工学会[編], コロナ社.

総説・解説記事

1. 【竜門賞受賞記念解説】単一および多体カプセルの流動に関する 膜-流体連成解析.
   武石直樹. ながれ2024年4月号, 43巻2号, 109-114, 2024.


2. 【学会参加記】The 3rd World Congress of the ESCHM-ISCH-ISB (Regensburg, Germany).
   武石直樹. 日本バイオレオロジー学会誌(B&R), 38巻1号, 20-21, 2024.


3. 【ポスト「京」重点課題2 -個別化・予防医療を支援する統合計算生命科学-】脳微小循環のダイナミクスと脳機能.
   武石直樹, 正本和人, 伊井仁志, 和田成生. News Letter, Vol.19, 1-7, 2019.


4. 【特集：固液・気液二相流の対流・物質輸送】血球細胞と対流物質輸送.
   武石直樹, 伊井仁志, 和田成生. 伝熱2019年1月号, 58巻242号, 22-29, 2019.


5. 【特集：注目研究in年会2018】赤血球希薄懸濁液と濃厚懸濁液のレオロジーを繋ぐ数値解析.
   武石直樹, Marco E. Rosti, 今井陽介, 和田成生, Luca Brandt. ながれ2018年12月号, 37巻6号, 516-519, 2018.


6. 【海外混相流事情】血液レオロジーの数値解析に関する国際共同研究 (スウェーデン王立工科大学にて).
   武石直樹. 混相流2018年12月号, 32巻4号, 454-457, 2018.

取材

1. 【次世代の担い手たち】生命活動を支える生体内の流れを流体力学の視点で捉えたい.
   武石直樹. 日経サイエンス2018年4月号, 1-2, 2018.


2. Interview with JSPS fellows in the U.S.
   Naoki Takeishi. JSPS San Francisco Newsletter, Vol. 34, p.11, Jul. 2014.